Cell-Permeable Esters of Diazeniumdiolate-Based Nitric Oxide Prodrugs

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• 作者：Harinath Chakrapani ; Anna E. Maciag ; Michael L. Citro ; Larry K. Keefer ; Joseph E. Saavedra
• 刊名：Organic Letters
• 出版年：2008
• 出版时间：November 20, 2008
• 年：2008
• 卷：10
• 期：22
• 页码：5155-5158
• 全文大小：161K
• 年卷期：v.10,no.22(November 20, 2008)
• ISSN：1523-7052

文摘

Although O²-(2,4-dinitrophenyl) derivatives of diazeniumdiolate-based nitric oxide (NO) prodrugs bearing a free carboxylic acid group were activated by glutathione to release NO, these compounds were poor sources of intracellular NO and showed diminished antiproliferative activity against human leukemia HL-60 cells. The carboxylic acid esters of these prodrugs, however, were found to be superior sources of intracellular NO and potent inhibitors of HL-60 cell proliferation.