Ruthenium(0)-Catalyzed sp3 C鈥揌 Bond Arylation of Benzylic Amines Using Arylboronates

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• 作者：Navid Dastbaravardeh ; Michael Schn眉rch ; Marko D. Mihovilovic
• 刊名：Organic Letters
• 出版年：2012
• 出版时间：April 6, 2012
• 年：2012
• 卷：14
• 期：7
• 页码：1930-1933
• 全文大小：273K
• 年卷期：v.14,no.7(April 6, 2012)
• ISSN：1523-7052

文摘

A Ru-catalyzed direct arylation of benzylic sp³ carbons of acyclic amines with arylboronates is reported. This highly regioselective and efficient transformation can be performed with various combinations of N-(2-pyridyl) substituted benzylamines and arylboronates. Substitution of the pyridine directing group in the 3-position proved to be crucial in order to achieve high arylation yields. Furthermore, the pyridine directing group can be removed in high yields via a two-step protocol.