Indazole-Type Alkaloids from Nigella sativa Seeds Exhibit Antihyperglycemic Effects via AMPK Activation in Vitro

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• 作者：Tao Yuan ; Pragati Nahar ; Meenakshi Sharma ; Ke Liu ; Angela Slitt ; H. A. Aisa ; Navindra P. Seeram
• 刊名：Journal of Natural Products
• 出版年：2014
• 出版时间：October 24, 2014
• 年：2014
• 卷：77
• 期：10
• 页码：2316-2320
• 全文大小：245K
• ISSN：1520-6025

文摘

Six rare naturally occurring indazole-type alkaloids including two new compounds, 17-O-(尾-pan class="smallcaps">dpan>-glucopyranosyl)-4-O-methylnigellidine (1) and nigelanoid (2), and four known compounds (3鈥?b>6) were isolated from a defatted extract of Nigella sativa (black cumin) seeds. 17-O-(尾-pan class="smallcaps">dpan>-Glucopyranosyl)-4-O-methylnigellidine (1) increased glucose consumption by liver hepatocytes (HepG2 cells) through activation of AMP-activated protein kinase (AMPK). Also, this is the first report of compounds 4 and 6 from a natural source.