Six rare naturally occurring indazole-type alkaloids including two new compounds, 17-O-(尾-pan class="smallcaps">dpan>-glucopyranosyl)-4-O-methylnigellidine (1) and nigelanoid (2), and four known compounds (3鈥?b>6) were isolated from a defatted extract of Nigella sativa (black cumin) seeds. 17-O-(尾-pan class="smallcaps">dpan>-Glucopyranosyl)-4-O-methylnigellidine (1) increased glucose consumption by liver hepatocytes (HepG2 cells) through activation of AMP-activated protein kinase (AMPK). Also, this is the first report of compounds 4 and 6 from a natural source.
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