Catalytic Rearrangement of Aldoximes to Primary Amides in Environmentally Friendly Media under Thermal and Microwave Heating: Another Application of the Bis(allyl)-Ruthenium(IV) Dimer [{RuCl(渭-Cl)(畏3:

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• 作者：Pedro J. Gonz谩lez-Liste ; Victorio Cadierno ; Sergio E. Garc铆a-Garrido
• 刊名：ACS Sustainable Chemistry & Engineering
• 出版年：2015
• 出版时间：November 2, 2015
• 年：2015
• 卷：3
• 期：11
• 页码：3004-3011
• 全文大小：440K
• ISSN：2168-0485

文摘

The rearrangement of aldoximes to primary amides has been studied using the commercially available bis(allyl)-ruthenium(IV) complex [{RuCl(渭-Cl)(畏³:畏³-C₁₀H₁₆)}₂] (1; C₁₀H₁₆ = 2,7-dimethylocta-2,6-diene-1,8-diyl) as a catalyst under thermal and microwave heating. The reactions proceeded cleanly in a mixture of water/glycerol (1:1) at 120鈥?50 掳C, without the assistance of any cocatalyst, affording the desired amides in moderate to high yields and short times. The process was operative with aromatic, heteroaromatic, aliphatic, and 伪,尾-unsaturated aldoximes and tolerated the presence of several functional groups in the substrates. In addition, the recyclability of catalyst 1 (up to six consecutive runs) could be demonstrated.