Palladium-Catalyzed Benzylic Addition of 2-Methyl Azaarenes to N-Sulfonyl Aldimines via C−H Bond Activation

详细信息    查看全文

• 作者：Bo Qian ; Shengmei Guo ; Jianping Shao ; Qiming Zhu ; Lei Yang ; Chungu Xia ; Hanmin Huang
• 刊名：Journal of the American Chemical Society
• 出版年：2010
• 出版时间：March 24, 2010
• 年：2010
• 卷：132
• 期：11
• 页码：3650-3651
• 全文大小：166K
• 年卷期：v.132,no.11(March 24, 2010)
• ISSN：1520-5126

文摘

An efficient protocol for the generation of amines by palladium-catalyzed nucleophilic benzylic addition of 2-methyl-substituted azaarenes to N-sulfonyl aldimines under neutral conditions via C−H bond activation has been developed. This reaction represents a very efficient methodology for the synthesis of heterocycle-containing amines and thus opens a new way to access amines through C−H bond activation.