Carolignans from the Aerial Parts of Euphorbia sikkimensis and Their Anti-HIV Activity

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• 作者：Cheng Jiang ; Pan Luo ; Yu Zhao ; Jialing Hong ; Susan L. Morris-Natschke ; Jun Xu ; Chin-Ho Chen ; Kuo-Hsiung Lee ; Qiong Gu
• 刊名：Journal of Natural Products
• 出版年：2016
• 出版时间：March 25, 2016
• 年：2016
• 卷：79
• 期：3
• 页码：578-583
• 全文大小：370K
• ISSN：1520-6025

文摘

Seven new carolignans, including two pairs of enantiomers (±)-erythro-7′-methylcarolignan E (1a/1b) and (±)-threo-7′-methylcarolignan E (2a/2b), (+)-threo-carolignan E (3a), (+)-erythro-carolignan E (4a), and (−)-erythro-carolignan Z (5), together with four known lignans (3b, 4b, 6, and 7) and six polyphenols (8–13) were isolated from the aerial parts of Euphorbia sikkimensis. The structures of the new compounds were elucidated by spectroscopic analysis, and their absolute configurations were determined by electronic circular dichroism calculations. Seven of the isolates were examined for anti-HIV effects, and compounds 1a and 1b showed moderate anti-HIV activity with EC₅₀ values of 6.3 and 5.3 μM.