Euphomilones A and B, ent-Rosane Diterpenoids with 7/5/6 and 5/7/6 Skeletons from Euphorbia milii

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• 作者：Shao-Nan Liu ; Dane Huang ; Susan L. Morris-Natschke ; Hang Ma ; Zhi-hong Liu ; Navindra P. Seeram ; Jun Xu ; Kuo-Hsiung Lee ; Qiong Gu
• 刊名：Organic Letters
• 出版年：2016
• 出版时间：December 2, 2016
• 年：2016
• 卷：18
• 期：23
• 页码：6132-6135
• 全文大小：343K
• ISSN：1523-7052

文摘

Three highly modified ent-rosane diterpenoids, euphomilones A (1) and B (2) and euphomianol A (3), were isolated from the aerial parts of Euphorbia milii. The structures were elucidated from physical, spectroscopic, and X-ray diffraction data, as well as experimental and calculated electronic circular dichroism (ECD) analysis. Plausible biogenetic pathways to 1–3 are proposed. Also, compound 1 exhibited inhibition of receptor activator of nuclear factor-kappaB ligand (RANKL)-induced osteoclast formation (IC₅₀ = 12.6 μM).