Ultralow Fouling Zwitterionic Polymers Grafted from Surfaces Covered with an Initiator via an Adhesive Mussel Mimetic Linkage

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• 作者：Guozhu Li ; Hong Xue ; Gang Cheng ; Shengfu Chen ; Fengbao Zhang ; Shaoyi Jiang
• 刊名：Journal of Physical Chemistry B
• 出版年：2008
• 出版时间：December 4, 2008
• 年：2008
• 卷：112
• 期：48
• 页码：15269-15274
• 全文大小：247K
• 年卷期：v.112,no.48(December 4, 2008)
• ISSN：1520-5207

文摘

In this work, nonfouling zwitterionic polymers were grafted via surface-initiated atom transfer radical polymerization (ATRP) from surfaces covered with an adhesive catechol initiator. The catechol initiator was attached to both bare gold and amino-functionalized surfaces, and the nonfouling performances of the resulting polymer brushes were compared. Under optimal conditions, ultralow protein adsorption from both single-protein solutions of fibrinogen and lysozyme and complex media of 10% blood serum and 100% blood plasma/serum was achieved. Furthermore, the 3-day accumulation of Pseudomonas aeruginosa on the treated glass surfaces was studied in situ using a laminar flow chamber. The results showed that these zwitterionic coatings dramatically reduced the biofilm formation of P. aeruginosa as compared to the reference bare glass.