Isolation, Structure Elucidation, Biosynthesis, and Synthesis of Antalid, a Secondary Metabolite from Polyangium species

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• 作者：Thomas Tautz ; Judith Hoffmann ; Thomas Hoffmann ; Heinrich Steinmetz ; Peter Washausen ; Brigitte Kunze ; Volker Huch ; Andreas Kitsche ; Hans Reichenbach ; Gerhard Höfle ; Rolf Müller ; Markus Kalesse
• 刊名：Organic Letters
• 出版年：2016
• 出版时间：June 3, 2016
• 年：2016
• 卷：18
• 期：11
• 页码：2560-2563
• 全文大小：364K
• 年卷期：0
• ISSN：1523-7052

文摘

The isolation, structure elucidation, and synthesis of antalid (1), a novel secondary metabolite from Polyangium sp., is described herein. The structure elucidation of 1 was performed with the aid of mass spectrometry, high field NMR experiments, and crystal structure analysis. The absolute configuration of antalid was confirmed through the Mosher ester method and ultimately by total synthesis. In addition, the biosynthetic origin of this hybrid PKS-NRPS natural product was unraveled by the in silico analysis of its biosynthetic gene cluster.