Synthesis of Highly Functionalized Chiral 3,3鈥?Disubstituted Oxindoles via an Organocatalytic Enantioselective Michael Addition of Nitroalkanes to Indolylidenecyanoacetates

详细信息    查看全文

• 作者：Lu Liu ; Deyan Wu ; Shu Zheng ; Tengfei Li ; Xiangmin Li ; Sinan Wang ; Jian Li ; Hao Li ; Wei Wang
• 刊名：Organic Letters
• 出版年：2012
• 出版时间：January 6, 2012
• 年：2012
• 卷：14
• 期：1
• 页码：134-137
• 全文大小：759K
• 年卷期：v.14,no.1(January 6, 2012)
• ISSN：1523-7052

文摘

An efficient bifunctional cinchona alkaloid derived thiourea-promoted enantioselective conjugate addition of nitroalkanes to indolylidenecyanoacetates has been developed under neat conditions. The process leads to synthetically interesting densely functionalized 3,3鈥?disubstituted oxindoles with creation of up to three stereogenic centers.