Measurement and Correlation of Solubility of Azithromycin Monohydrate in Five Pure Solvents

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• 作者：Xuemei Wang ; Yanan Qin ; Tianwei Zhang ; Weiwei Tang ; Boai Ma ; Junbo Gong
• 刊名：Journal of Chemical & Engineering Data
• 出版年：2014
• 出版时间：March 13, 2014
• 年：2014
• 卷：59
• 期：3
• 页码：784-791
• 全文大小：310K
• 年卷期：v.59,no.3(March 13, 2014)
• ISSN：1520-5134

文摘

The solubility of azithromycin monohydrate in ethanol, propan-2-ol, butan-1-ol, ethyl ethanoate, and 2-propanone from 278.15 K to 323.15 K was measured by a synthetic method. The measured solubility data were correlated by van鈥檛 Hoff equation, modified Apelblat equation, 位h equation, Wilson, and NRTL models. It was found that the Wilson equations give the best correlation results. The mixing properties including the mixing free Gibbs energy, enthalpy, and entropy of azithromycin monohydrate were also calculated based on the Wilson model parameters. The results indicate that the dissolution process of azithromycin monohydrate in all tested solvents is spontaneous and endothermic.