[3 + 2] Cycloaddition of Oxazol-5-(4H)-ones with Nitrones for Diastereoselective Synthesis of Isoxazolidin-5-ones

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• 作者：Hong-Wu ZhaoYue-Yang Liu ; Yu-Di Zhao ; Hai-Liang Pang ; Xiao-Qin Chen ; Xiu-Qing Song ; Ting Tian ; Bo Li ; Zhao Yang ; Juan Du ; Ning-Ning Feng
• 刊名：Organic Letters
• 出版年：2017
• 出版时间：January 6, 2017
• 年：2017
• 卷：19
• 期：1
• 页码：26-29
• 全文大小：316K
• ISSN：1523-7052

文摘

In the presence of TMSCl, the [3 + 2] cycloaddition of oxazol-5-(4H)-ones with nitrones proceeded smoothly and furnished the desired isoxazolidin-5-ones with high diastereoselectivities in reasonable chemical yields. The chemical structure of the title compounds was firmly confirmed by X-ray single-crystal structure analysis.