Metal-Free [3 + 2 + 1]/[2 + 2 + 1] Biscyclization: Stereospecific Construction with Concomitant Functionalization of Indolizin-5(1H)-one

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• 作者：Tuan-Jie Li ; Zhong-Qiu Liu ; Hong-Mei Yin ; Chang-Sheng Yao ; Bo Jiang ; Xiang-Shan Wang ; Shu-Jiang Tu ; Xiu-Ling Li ; Guigen Li
• 刊名：Journal of Organic Chemistry
• 出版年：2013
• 出版时间：November 15, 2013
• 年：2013
• 卷：78
• 期：22
• 页码：11414-11420
• 全文大小：327K
• 年卷期：v.78,no.22(November 15, 2013)
• ISSN：1520-6904

文摘

A metal-free [3 + 2 + 1]/[2 + 2 + 1] biscyclization strategy has been developed for the stereospecific construction with concomitant derivation of biologically significant indolizin-5(1H)-ones from simple and commercial starting materials. The transformations are notable because they can yield five new 蟽 bonds and six stereocenters including a quaternary carbon center in a single operation.