Catalytic Sulfur-Enabled Dehydrobicyclization of 1,6-Enynes toward Arylated Indeno[1,2-c]thiophenes

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• 作者：Ya-Nan Wu ; Rong Fu ; Nan-Nan Wang ; Wen-Juan Hao ; Guigen Li ; Shu-Jiang Tu ; Bo Jiang
• 刊名：Journal of Organic Chemistry
• 出版年：2016
• 出版时间：June 3, 2016
• 年：2016
• 卷：81
• 期：11
• 页码：4762-4770
• 全文大小：441K
• 年卷期：0
• ISSN：1520-6904

文摘

A new copper-catalyzed sulfur-enabled dehydrobicyclization of 1,6-enynes using potassium sulfide as a sulfurating reagent has been established, providing a straightforward access toward arylated indeno[1,2-c]thiophenes with moderate to good yields. This sulfur incorporation pathway involves Michael addition, 5-exo-dig/5-endo-trig bicyclization and dehydrogenation sequence, resulting in continuous multiple bond-forming events including C–S and C–C bonds to rapidly construct functional organic molecules.