Versicoamides F–H, Prenylated Indole Alkaloids from Aspergillus tennesseensis

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• 作者：Li Liu ; Long Wang ; Li Bao ; Jinwei Ren ; Buddha Bahadur Basnet ; Ruixing Liu ; Luwei He ; Junjie Han ; Wen-Bing Yin ; Hongwei Liu
• 刊名：Organic Letters
• 出版年：2017
• 出版时间：February 17, 2017
• 年：2017
• 卷：19
• 期：4
• 页码：942-945
• 全文大小：300K
• ISSN：1523-7052

文摘

Three highly modified indole alkaloids, versicoamides F–H (1–3), together with seven known alkaloids (4–10) were isolated from the fungus Aspergillus tennesseensis. The structures of new compounds were determined by analysis of the NMR and MS spectroscopic data. The absolute configurations of 1 and 2 were assigned by single-crystal X-ray diffraction experiments. Compounds 1 and 2 showed weak antiproliferative activity against the H460 cell line. Compounds 1–3 represent a new class of natural product hybrids with new chemical skeletons.