Metal-Free Oxidative Radical Alkynylation/Ring Expansion Rearrangement of Alkenyl Cyclobutanols with Ethynylbenziodoxolones

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• 作者：Ruo-Yi Zhang ; Long-Yi Xi ; Lei Shi ; Xiao-Zhuan Zhang ; Shan-Yong Chen ; Xiao-Qi Yu
• 刊名：Organic Letters
• 出版年：2016
• 出版时间：August 19, 2016
• 年：2016
• 卷：18
• 期：16
• 页码：4024-4027
• 全文大小：365K
• 年卷期：0
• ISSN：1523-7052

文摘

The first metal-free alkynylation/ring expansion cascade process of alkenyl cyclobutanols with ethynylbenziodoxolones has been developed. A variety of synthetically valuable β-alkynylated cyclopentanones were prepared in moderate to good yields. Alkynyl cyclobutanols could also undergo this transformation, providing a new approach to substituted ene-yne-carbonyl compounds.