Asymmetric Total Synthesis of (鈭?-Jorunnamycins A and C and (鈭?-Jorumycin from l-Tyrosine

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• 作者：Ruijiao Chen ; Hao Liu ; Xiaochuan Chen
• 刊名：Journal of Natural Products
• 出版年：2013
• 出版时间：September 27, 2013
• 年：2013
• 卷：76
• 期：9
• 页码：1789-1795
• 全文大小：365K
• 年卷期：v.76,no.9(September 27, 2013)
• ISSN：1520-6025

文摘

Three renieramycin-type antitumor alkaloids, (鈭?-jorunnamycins A (1) and C (2) and (鈭?-jorumycin (3), have been synthesized by a new convergent approach, which features a highly regio- and stereoselective Pictet鈥揝pengler cyclization to couple the isoquinoline and the trisubstituted phenylalaninol partners. This synthetic strategy opens an economical access to these important antitumor alkaloids with high yields: (鈭?-jorunnamycin A, as a common precursor to other renieramycin-type alkaloids and their analogues, is obtained with 18.1% overall yield from l-tyrosine.