Synthesis of N-(2-Pyridyl)indoles via Pd(II)-Catalyzed Oxidative Coupling

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• 作者：Jinlei Chen ; Qingyu Pang ; Yanbo Sun ; Xingwei Li
• 刊名：Journal of Organic Chemistry
• 出版年：2011
• 出版时间：May 6, 2011
• 年：2011
• 卷：76
• 期：9
• 页码：3523-3526
• 全文大小：788K
• 年卷期：v.76,no.9(May 6, 2011)
• ISSN：1520-6904

文摘

Readily available Pd(II) chloride catalysts can catalyze selective and efficient oxidative coupling between N-aryl-2-aminopyridines and internal alkynes to yield N-(2-pyridyl)indoles. This process involves the ortho C鈭扝 activation of N-aryl-2-aminopyridines, and CuCl₂ was used as an oxidant. Compared to our previously reported Rh(III)-catalyzed synthesis of this class of product, this method is advantageous with a wider scope of alkynes and cost-effective Pd(II) catalysts. Molecular oxygen can be used as a terminal oxidant.