Multifunctional Nanotherapeutics with All-in-One Nanoentrapment of Drug/Gene/Inorganic Nanoparticle

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• 作者：Hui-Zhen Jia ; Wei Wang ; Di-Wei Zheng ; Xuli Wang ; Wu-Yang Yu ; Shi-Ying Li ; Ren-Xi Zhuo ; Yi-Fang Zhao ; Jun Feng ; Xian-Zheng Zhang
• 刊名：ACS Applied Materials & Interfaces
• 出版年：2016
• 出版时间：March 23, 2016
• 年：2016
• 卷：8
• 期：11
• 页码：6784-6789
• 全文大小：379K
• ISSN：1944-8252

文摘

It is challenging but imperative to merge together specific inorganic nanomaterials with macromolecular and small-molecule therapeutics into one nanoentity for all-in-one theranostic/remedy. We establish a versatile nanotechnology to nanoentrap magnetic nanoparticles, doxorubicin, and DNA, thus allowing the combination of magnetic targeting, magnetic resonance (MR) imaging, gene transport, and bioresponsive chemotherapy. We hope this nanotechnology can prompt the development of complex inorganic/organic nanosystems for various applications.