The Synthesis of Multisubstituted Pyrroles via a Copper-Catalyzed Tandem Three-Component Reaction

详细信息    查看全文

• 作者：Xue-Qing Mou ; Zheng-Liang Xu ; Li Xu ; Shao-Hua Wang ; Bang-Hong Zhang ; Di Zhang ; Jie Wang ; Wei-Ting Liu ; Wen Bao
• 刊名：Organic Letters
• 出版年：2016
• 出版时间：August 19, 2016
• 年：2016
• 卷：18
• 期：16
• 页码：4032-4035
• 全文大小：353K
• 年卷期：0
• ISSN：1523-7052

文摘

An unprecedented nucleophilic addition/cyclization/aromatization cascade of basic chemicals, i.e., aromatic alkenes/alkynes, trimethylsilyl cyanide and N,N-disubstituted formamide, has been developed to give a series of multisubstituted pyrroles in moderate to good yields with high regioselectivities. This reaction not only reveals a new reaction mode for α-aminonitriles, but also provides a new and efficient cyclization pattern for the synthesis of multisubstituted pyrroles as well as their derivatives, which might facilitate related biological studies.