Effects of Zinc Supplementation on the Element Distribution in Kidney Tissue of Diabetic Rats Subjected to Acute Swimming

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• 作者：Abdullah Sivrikaya (1)
  Mursel Bicer (2)
  Mustafa Akil (3)
  Abdulkerim Kasim Baltaci (4)
  Rasim Mogulkoc (4)
  
• 关键词：Diabetes ; Exercise ; Zinc supplementation ; Kidney ; Zinc metabolism
• 刊名：Biological Trace Element Research
• 出版年：2012
• 出版时间：June 2012
• 年：2012
• 卷：147
• 期：1-3
• 页码：195-199
• 全文大小：116KB
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• 作者单位：Abdullah Sivrikaya (1)
  Mursel Bicer (2)
  Mustafa Akil (3)
  Abdulkerim Kasim Baltaci (4)
  Rasim Mogulkoc (4)
  
  1. Department of Biochemistry, Selcuklu School of Medicine, Sel?uk University, Konya, Turkey
  2. School of Physical Education and Sports, Sel?uk University, Konya, Turkey
  3. Hasan Dogan High School of Physical Education and Sports, Karabuk University, Karabuk, Turkey
  4. Department of Physiology, Selcuklu Medical School, Selcuk University, Campus, 42031, Sel?uklu, Konya, Turkey
  

文摘

In this study, we report the effect of zinc supplementation on the distribution of elements in kidney tissue of diabetic rats subjected to acute swimming exercise. Diabetes was induced by two subcutaneous injections of 40?mg/kg of streptozotocin within a 24-h period. Zinc was given intraperitoneally at a dose of 6?mg/kg per day for a period of 4?weeks. The rats (n--0) were equally divided into eight study groups: controls, zinc-supplemented, swimming, diabetic, zinc-supplemented diabetic, zinc-supplemented swimming, diabetic swimming, and zinc-supplemented diabetic swimming. The levels of lead, cobalt, molybdenum, chromium, boron, magnesium, iron, copper, calcium, zinc, and selenium were determined in the kidney tissue samples by ICP-AES. Higher molybdenum, calcium, zinc, and selenium values were found in both swimming and nonswimming diabetic rats. Significantly higher iron values were found in swimming, diabetic, diabetic swimming, and zinc-supplemented diabetic swimming rats (p-lt;-.001). Diabetic, zinc-supplemented diabetic, diabetic swimming, and zinc-supplemented diabetic swimming rats had the highest copper values. These results show that zinc supplementation normalized the higher levels of molybdenum, calcium, selenium, and iron levels seen in diabetic rats, indicating that zinc may have a regulatory effect on element metabolism in kidney tissue.