Substrate specificity and function of acetylpolyamine amidohydrolases from Pseudomonas aeruginosa

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• 作者：Andreas Krämer ; Jan Herzer ; Joerg Overhage ; Franz-Josef Meyer-Almes
• 关键词：Acetylpolyamine amidohydrolases ; Pseudomonas aeruginosa ; Substrate specificity ; Acetylpolyamines ; Polyamine metabolism
• 刊名：BMC Biochemistry
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：17
• 期：1
• 全文大小：3,730 KB
• 刊物主题：Biochemistry, general; Life Sciences, general;
• 出版者：BioMed Central
• ISSN：1471-2091

文摘

Background Pseudomonas aeruginosa, a Gram-negative, aerobic coccobacillus bacterium is an opportunistic human pathogen and worldwide the fourth most common cause of hospital-acquired infections which are often high mortality such as ventilator-associated pneumoniae. The polyamine metabolism of P. aeruginosa and particularly the deacetylation of acetylpolyamines has been little studied up to now. Results with other bacterial pathogens e.g., Y. pestis suggest that polyamines may be involved in the formation of biofilms or confer resistance against certain antibiotics.