Case-control study of candidate gene methylation and adenomatous polyp formation

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• 作者：M. Alexander ; J. B. Burch ; S. E. Steck…
• 关键词：Adenomatous polyp ; Circadian rhythm ; Colorectal cancer ; Screening tests
• 刊名：International Journal of Colorectal Disease
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：32
• 期：2
• 页码：183-192
• 全文大小：
• 刊物类别：Medicine
• 刊物主题：Surgery; Internal Medicine; Gastroenterology; Hepatology; Proctology;
• 出版者：Springer Berlin Heidelberg
• ISSN：1432-1262
• 卷排序：32

文摘

PurposeColorectal cancer (CRC) is one of the most common and preventable forms of cancer but remains the second leading cause of cancer-related death. Colorectal adenomas are precursor lesions that develop in 70–90 % of CRC cases. Identification of peripheral biomarkers for adenomas would help to enhance screening efforts. This exploratory study examined the methylation status of 20 candidate markers in peripheral blood leukocytes and their association with adenoma formation.