Does sildenafil have protective effects against ovarian ischemia-reperfusion injury in rats?

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• 作者：Adnan Incebiyik ; Ahmet Seker ; Hakan Camuzcuoglu…
• 关键词：Adnexal torsion ; Ischemia ; reperfusion injury ; Sildenafil ; Rat model
• 刊名：Archives of Gynecology and Obstetrics
• 出版年：2015
• 出版时间：June 2015
• 年：2015
• 卷：291
• 期：6
• 页码：1283-1288
• 全文大小：1,624 KB
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  8.Inan M, Uz YH, Kizilay G, Topcu TY, Sapmaz MM, Akpolat M et al (2013) Protective effect of sildenafil on liver injury induced by intestinal ischemia/reperfusion. J Pediatr Surg 48:1707-715View Article PubMed
  9.Shih PK, Cheng CM, Li HP, Huang MF, Chiu CW, Chen JX et al (2013) Pretreatment with sildenafil alleviates early lung ischemia-reperfusion injury in a rat model. J Surg Res 185:77-3View Article
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• 作者单位：Adnan Incebiyik (1)
  Ahmet Seker (2)
  Hakan Camuzcuoglu (1)
  Sezen Kocaslan (3)
  Aysun Camuzcuoglu (1)
  Nese Gul Hilali (1)
  Mehmet Vural (4)
  Abdullah Taskin (5)
  Nurten Aksoy (5)
  
  1. Department of Gynecology and Obstetrics, Harran University School of Medicine, Yenisehir Campus, 63300, Sanl?urfa, Turkey
  2. Department of General Surgery, Faculty of Medicine, Harran University, Sanliurfa, Turkey
  3. Department of Pathology, Faculty of Medicine, Harran University, Sanliurfa, Turkey
  4. Department of Gynecology and Obstetrics, Faculty of Medicine, Marmara University, Istanbul, Turkey
  5. Department of Biochemistry, Faculty of Medicine, Harran University, Sanliurfa, Turkey
  
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Gynecology
  Obstetrics and Perinatology
  Endocrinology
  Human Genetics
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1432-0711

文摘

Purpose The aim of this study was to evaluate the protective activity of sildenafil treatment against ischemia-reperfusion damage created experimentally in rat ovaries. Methods For this study, 42 female Wistar rats were used, and the rats were separated randomly into six groups consisting of seven rats each: sham, torsion, torsion-detorsion, torsion-detorsion?+?saline, torsion-detorsion?+?sildenafil 0.7?mg/kg and torsion-detorsion?+?sildenafil 1.4?mg/kg. With the exception of the sham group, an ovarian torsion procedure was implemented in all other groups for 2?h. Then, a detorsion procedure was implemented to the groups for 2?h, with the exception of the torsion group. Medications were given intraperitoneally, one-half hour before the detorsion procedure in the saline, 0.7 and 1.4?mg/kg sildenafil groups. Finally, 2?ml of blood samples was drawn for markers of oxidative stress, while the ovaries which were torsioned for the histological examination were extracted from all rats. Results According to the histopathological damage scores, the least damage was seen in the sham group and the most damage was seen in the torsion-detorsion group. The sildenafil treatment appeared to be effective in decreasing tissue damage; however, there were no differences between the dosages. Additionally, it was determined that the oxidative stress levels were higher in the torsion-detorsion group, while the sildenafil treatment caused a significant decrease in the oxidative stress levels. Conclusions The results of the current study showed that the sildenafil treatment can be effective in preventing tissue damage and oxidative stress induced by the ischemia-reperfusion created in rat ovaries.