Comparison of estimated human effective dose of 67Ga- and 99mTc-labeled bombesin based on distribution data in mice

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• 作者：Saeed Shanehsazzadeh ; Afsaneh Lahooti…
• 关键词：Gallium 67 ; Technetium 99m ; Bombesin ; Biodistribution ; Effective dose ; Dosimetry ; MIRD
• 刊名：Journal of Radioanalytical and Nuclear Chemistry
• 出版年：2015
• 出版时间：August 2015
• 年：2015
• 卷：305
• 期：2
• 页码：513-520
• 全文大小：597 KB
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• 作者单位：Saeed Shanehsazzadeh (1)
  Afsaneh Lahooti (2)
  Seyed Pezhman Shirmardi (3) (4)
  Mostafa Erfani (1)
  
  1. Radiation Application Research School, Nuclear Science and Technology Research Institute (NSTRI), P.O.Box:11365-3486, Tehran, Iran
  2. Department of Medical Physics and Biomedical Engineering, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  3. Central Iran Research Complex (Yazd), Nuclear Science and Technology Research Institute (NSTRI), Tehran, Iran
  4. Nuclear Fuel Cycle Research School, Nuclear Science and Technology Research Institute (NSTRI), Tehran, Iran
  
• 刊物类别：Chemistry and Materials Science
• 刊物主题：Chemistry
  Nuclear Chemistry
  Physical Chemistry
  Nuclear Physics, Heavy Ions and Hadrons
  Diagnostic Radiology
  Inorganic Chemistry
  
• 出版者：Akad茅miai Kiad贸, co-published with Springer Science+Business Media B.V., Formerly Kluwer Academic
• ISSN：1588-2780

文摘

This study describes the preparation, biodistribution and absorbed dose prediction of 67Ga and 99mTc labeled bombesin (BBN) in human organs, after injection in mice determined via medical internal radiation dose. We estimated that a 185-MBq injection of 67Ga-BBN into the humans would result in an estimated effective absorbed dose of 2.50?mSv whereas this value for 99mTc-BBN is 1.33?mSv in the whole body. These results suggest that injection of 67Ga-BBN would result 2 times higher absorbed dose compare to 99mTc-BBN.