Combining aneuploidy and dysplasia for colitis’ cancer risk assessment outperforms current surveillance efficiency: a meta-analysis

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• 作者：Rüdiger Meyer ; Sandra Freitag-Wolf…
• 关键词：Ulcerative colitis ; associated colorectal carcinoma ; Nuclear DNA ploidy ; Cancer risk assessment ; Meta ; analysis
• 刊名：International Journal of Colorectal Disease
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：32
• 期：2
• 页码：171-182
• 全文大小：
• 刊物类别：Medicine
• 刊物主题：Surgery; Internal Medicine; Gastroenterology; Hepatology; Proctology;
• 出版者：Springer Berlin Heidelberg
• ISSN：1432-1262
• 卷排序：32

文摘

PurposeCancer risk assessment for ulcerative colitis patients by evaluating histological changes through colonoscopy surveillance is still challenging. Thus, additional parameters of high prognostic impact for the development of colitis-associated carcinoma are necessary. This meta-analysis was conducted to clarify the value of aneuploidy as predictor for individual cancer risk compared with current surveillance parameters.