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Muscarinic M1 Receptors Regulate Propofol Modulation of GABAergic Transmission in Rat Ventrolateral Preoptic Neurons
- 作者:Yu Zhang (1)
Tian Yu (2) Yang Liu (2) Kun Qian (2) Bu-Wei Yu (1)
1. Department of Anesthesiology ; Ruijin Hospital ; Shanghai Jiao Tong University School of Medicine ; 197 Ruijin Er Road ; Shanghai ; 200025 ; People鈥檚 Republic of China 2. Guizhou Key Laboratory of Anesthesia and Organ Protection ; Zunyi Medical College ; Zunyi ; Guizhou ; People鈥檚 Republic of China
- 关键词:Ventrolateral preoptic ; Propofol ; Acetylcholine ; 纬 ; aminobutyric acid
- 刊名:Journal of Molecular Neuroscience
- 出版年:2015
- 出版时间:April 2015
- 年:2015
- 卷:55
- 期:4
- 页码:830-835
- 全文大小:583 KB
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Li, KY, Guan, YZ, Krnjevic, K, Ye, JH (2009) Propofol facilitates glutamatergic transmission to neurons of the ventrolateral preoptic nucleus. Anesthesiology 111: pp. 1271-1278 CrossRef 15. Liu, YW, Zuo, W, Ye, JH (2013) Propofol stimulates noradrenalin-inhibited neurons in the ventrolateral preoptic nucleus by reducing GABAergic inhibition. Anesth Analg 117: pp. 358-363 CrossRef 16. Meuret, P, Backman, SB, Bonhomme, V, Plourde, G, Fiset, P (2000) Physostigmine reverses propofol-induced unconsciousness and attenuation of the auditory steady state response and bispectral index in human volunteers. Anesthesiology 93: pp. 708-717 542-200009000-00020" target="_blank" title="It opens in new window">CrossRef 17. Murasaki, O, Kaibara, M, Nagase, Y, Mitarai, S, Doi, Y, Sumikawa, K, Taniyama, K (2003) Site of action of the general anesthetic propofol in muscarinic M1 receptor-mediated signal transduction. 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- 刊物主题:Neurosciences; Neurochemistry; Cell Biology; Proteomics; Neurology;
- 出版者:Springer US
- ISSN:1559-1166
文摘
GABAergic neurons within the ventrolateral preoptic area (VLPO) play an important role in sleep-wakefulness regulation. Propofol, a widely used systemic anesthetic, has lately been reported to excite noradrenaline (NA)-inhibited type of VLPO neurons. Present study tested if acetylcholine system takes part in the propofol modulation of GABAergic spontaneous miniature inhibitory postsynaptic currents (mIPSCs) in mechanically dissociated rat VLPO neurons using a conventional whole-cell patch clamp technique. Propofol reversibly decreased mIPSC frequency without affecting the current amplitude, indicating that propofol acts presynaptically to decrease the probability of spontaneous GABA release. The propofol action on GABAergic mIPSC frequency was completely blocked by atropine, a nonselective muscarinic acetylcholine (mACh) receptor antagonist, and pirenzepine, a selective M1 receptor antagonist. These results suggest that propofol acts on M1 receptors on GABAergic nerve terminals projecting to VLPO neurons to inhibit spontaneous GABA release. The M1 receptor-mediated modulation of GABAergic transmission onto VLPO neurons may contribute to the regulation of loss of consciousness induced by propofol.
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