ApoA5-1131T→C polymorphism and its effect on triglyceride level in type 2 diabetes patients with nephropathy

详细信息    查看全文

• 作者：Dina ELabd (1)
  Tarek Fayad (2)
  
• 关键词：Diabetic nephropathy ; ApoA5 ; 1131T→C ; Genotyping
• 刊名：Comparative Clinical Pathology
• 出版年：2014
• 出版时间：January 2014
• 年：2014
• 卷：23
• 期：1
• 页码：145-150
• 全文大小：149 KB
• 作者单位：Dina ELabd (1)
  Tarek Fayad (2)
  
  1. Department of Clinical and Chemical Pathology, Faculty of Medicine, Cairo University, Cairo, Egypt
  2. Department of Internal Medicine, Faculty of Medicine, Cairo University, Cairo, Egypt
  
• ISSN：1618-565X

文摘

Diabetic nephropathy (DN) is a major cause of end-stage renal disease. Epidemiological studies suggest genetic predisposition to DN. Apolipoprotein A5 (ApoA5) plays an important role in the triglyceride (TG) metabolism, accelerating the catabolism of the TG-rich lipoproteins. Studies revealed that the ApoA5-1131 polymorphism is strongly associated with TG levels affecting DN risk. Patients with DN have increased fasting plasma TG levels, and studies report that elevated TG precedes DN. To test the effect of polymorphism ApoA5-1131T→C on the elevated TG levels contributing to the development of DN on type 2 diabetes patients, the study was conducted on 40 diabetic patients divided into two groups according to the presence or absence of diabetic nephropathy (DN+ and DN?, compared to 20 age- and sex-matched apparently healthy controls. DNA analysis was performed using polymerase chain reaction–restriction fragment length polymorphism. ApoA5-1131 CC carriers had a higher mean TG in the DN+, DN? and control groups (TG 224, 201, and 204?mg/dl, respectively) (p--.001) compared to TT and TC carriers. Genotype distribution between controls and patients revealed CC carriers in the DN?and DN+ to be 55 and 45?%, respectively, compared to only 15?% in the control group (p--.001). Association between DN and the polymorphism (CC) that affects fasting TG is seen in this study (OR--.6, 95?% CI--.02-1, p--.001). ApoA5-1131 CC carriers are more susceptible to a higher fasting TG level and the development of DN.