Consumption of whole grains and legumes modulates the genetic effect of the APOA5 -1131C variant on changes in triglyceride and apolipoprotein A-V concentrations in patients with impaired fasting glucose or newly diagnosed ty

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• 作者：Ryungwoo Kang (27)
  Minjoo Kim (27) (28)
  Jey Sook Chae (29)
  Sang-Hyun Lee (30)
  Jong Ho Lee (27) (28) (29)
  
• 关键词：APOA5 ; 1131?T-gt ; ?C ; Whole grains and legumes ; Triglycerides ; Apolipoprotein A ; V
• 刊名：Trials
• 出版年：2014
• 出版时间：December 2014
• 年：2014
• 卷：15
• 期：1
• 全文大小：265 KB
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• 作者单位：Ryungwoo Kang (27)
  Minjoo Kim (27) (28)
  Jey Sook Chae (29)
  Sang-Hyun Lee (30)
  Jong Ho Lee (27) (28) (29)
  
  27. Department of Food and Nutrition, College of Human Ecology, National Leading Research Laboratory of Clinical Nutrigenetics/Nutrigenomics, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul, 120-749, Korea
  28. Department of Food and Nutrition, Brain Korea 21 PLUS Project, College of Human Ecology, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul, 120-749, Korea
  29. Yonsei University Research Institute of Science for Aging, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul, 120-749, Korea
  30. Department of Family Practice, National Health Insurance Corporation Ilsan Hospital, 100 ilsan-ro ilsan-donggu, Goyang, 410-719, Korea
  
• ISSN：1745-6215

文摘

Background The apolipoprotein A5 gene (APOA5) -1131?T-gt;?C polymorphism is associated with mild hypertriglyceridemia in type 2 diabetic subjects, and interacts with dietary fat in the determination of triglyceride concentrations. We examined whether a substitution of whole grains and legumes for refined rice in a high carbohydrate diet (about 65% of energy derived from carbohydrate) may modify the effect of this variant on changes in apolipoprotein A-V (apoA-V) and triglyceride concentrations. Methods We genotyped the APOA5 -1131?T-gt;?C in individuals with impaired fasting glucose (IFG) or newly diagnosed type 2 diabetes, who were randomly assigned to either a group ingesting whole grain and legume meals daily or a control group for 12?weeks. Results After dietary intervention, we observed significant interactions between the APOA5 -1131?T-gt;?C polymorphism and carbohydrate sources (whole grains and legumes versus refined rice) in the determination of mean percent changes in triglyceride and apoA-V (P interactions <0.001 and =0.038, respectively). In the refined rice group (n--3), the carriers of the risk C allele (n--0) showed a greater increase in the mean percent changes of triglyceride and apoA-V than noncarriers after adjusting for HOMA-IR (P--.004 and 0.021, respectively). The whole grain and legume group (n--2), however, showed a decrease in fasting glucose, HOMA-IR, and triglyceride, and an increase in apoA-V, irrespective of genotype. Conclusions The data showed that the magnitude of the genetic effect of the APOA5 -1131C variant on triglyceride and apoA-V levels was modulated when substituting consumption of whole grains and legumes for refined rice as a carbohydrate source in IFG or diabetic subjects. Trial registration ClinicalTrials.gov: NCT01784952.