Effects of a 3-year dietary intervention on age-related changes in triglyceride and apolipoprotein A-V levels in patients with impaired fasting glucose or new-onset type 2 diabetes as a function of the APOA5 -1131?T-gt;?C polymorphism

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• 作者：Minjoo Kim ; Jey Sook Chae ; Miri Kim ; Sang-Hyun Lee ; Jong Ho Lee
• 关键词：Apolipoprotein A ; V ; APOA5 ; 1131?T-gt ; ?C ; Diabetes ; Polymorphism
• 刊名：Nutrition Journal
• 出版年：2014
• 出版时间：December 2014
• 年：2014
• 卷：13
• 期：1
• 全文大小：248 KB
• 参考文献：1. Li, GP, Wang, JY, Yan, SK, Chen, BS, Xue, H, Wu, G (2004) Genetic effect of two polymorphisms in the apolipoprotein A5 gene and apolipoprotein C3 gene on serum lipids and lipoproteins levels in a Chinese population. Clin Genet 65: pp. 470-476 CrossRef
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  4. Baum, L, Tomlinson, B, Thomas, GN (2003) APOA5-1131?T-?C polymorphism is associated with triglyceride levels in Chinese men. Clin Genet 63: pp. 377-379 CrossRef
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  6. Dallinga-Thie, GM, Van Tol, A, Hattori, H, der Zee LC, VV-v, Jansen, H, Sijbrands, EJ (2006) Plasma apolipoprotein A5 and triglyceride in type 2 diabetes. Diabetologia 49: pp. 1505-1511 CrossRef
  7. Jang, Y, Kim, JY, Kim, OY, Lee, JE, Cho, H, Ordovas, JM, Lee, JH (2004) The -1131?T?→?C polymorphism in the apolipoprotein A5 gene is associated with postprandial hypertriacylglycerolemia; elevated small, dense LDL concentrations; and oxidative stress in nonobese Korean men. Am J Clin Nutr 80: pp. 832-840
  8. Xu, C, Bai, R, Zhang, D, Li, Z, Zhu, H, Lai, M, Zhu, Y (2013) Effects of APOA5-131?T-?C (rs662799) on fasting plasma lipids and risk of metabolic syndrome: evidence from a case–control study in China and a meta-analysis. PLoS One 8: pp. e56216 CrossRef
  9. Chandak, GR, Ward, KJ, Yajnik, CS, Pandit, AN, Bavdekar, A, Joglekar, CV, Fall, CH, Mohankrishna, P, Wilkin, TJ, Metcalf, BS, Weedon, MN, Frayling, TM, Hattersley, AT (2006) Triglyceride associated polymorphisms of the APOA5 gene have very different allele frequencies in Pune, India compared to Europeans. BMC Med Genet 7: pp. 76-81 CrossRef
  10. Sánchez-Moreno, C, Ordovás, JM, Smith, CE, Baraza, JC, Lee, YC, Garaulet, M (2011) APOA5 gene variation interacts with dietary fat intake to modulate obesity and circulating triglycerides in a Mediterranean population. J Nutr 141: pp. 380-385 CrossRef
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  12. Corella, D, Lai, CQ, Demissie, S, Cupples, LA, Manning, AK, Tucker, KL, Ordovas, JM (2007) APOA5 gene variation modulates the effects of dietary fat intake on body mass index and obesity risk in the Framingham Heart Study. J Mol Med (Berl) 85: pp. 119-128 CrossRef
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  14. Lai, CQ, Corella, D, Demissie, S, Cupples,
• 刊物类别：Chemistry and Materials Science
• 刊物主题：Nutrition
  Clinical Nutrition
  
• 出版者：BioMed Central
• ISSN：1475-2891

文摘

Background The purpose of this study was to estimate the effects of a 3-year dietary intervention on age-related changes in triglyceride and apolipoprotein (apo A-V) levels in patients with impaired fasting glucose (IFG) or new-onset type 2 diabetes as a function of the APOA5 -1131?T-?C polymorphism. Methods We genotyped the APOA5 -1131?T-?C polymorphism in 203 Korean individuals with IFG or new-onset type 2 diabetes for the TT (n--1), TC (n--8), and CC (n--4) alleles. Plasma apo A-V and triglyceride levels were evaluated at baseline and after a 3-year dietary intervention. Results Our results showed that HDL, glucose, insulin, HOMA-IR index, free fatty acids, and apo A-V decreased and brachial-ankle pulse wave velocity (ba-PWV) and malondialdehyde (MDA) increased at the 3-year follow-up visit compared with baseline. Plasma apo A-V levels were reduced in subjects with the C allele (TC or CC) (P--.036) and triglyceride levels were reduced in subjects with the TT allele (P--.047). Subjects with the C allele showed lower post-treatment apo A-V and higher post-treatment fasting triglyceride levels than subjects with the TT allele. Changes in apo A-V and triglyceride levels were negatively correlated in subjects with the TT allele and positively correlated in subjects with the C allele. Conclusions This study showed that the dietary intervention prevented an age-related increase in triglyceride levels in individuals with IFG or new-onset type 2 diabetes who possess the TT allele, but not the CT or CC allele, of the APOA5 -1131?T-?C polymorphism.