Bronchopulmonale Dysplasie und Langzeitfolgen

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• 作者：Dr. med. F. Urlichs
• 关键词：Bronchopulmonale Dysplasie ; Extrem Frühgeborene ; Pulmonale Hypertension ; Pulmonale Atelektase ; Hypoxie induzierter Faktor 1 ; Bronchopulmonary dysplasia ; Extremely premature ; Pulmonary hypertension ; Pulmonary atelectasis ; Hypoxia ; inducible factor 1
• 刊名：Der Pneumologe
• 出版年：2016
• 出版时间：February 2016
• 年：2016
• 卷：13
• 期：1
• 页码：51-57
• 全文大小：406 KB
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• 作者单位：Dr. med. F. Urlichs (1)
  
  1. Neonatologie und Kinderintensivmedizin, St. Franziskus-Hospital GmbH, Hohenzollernring 72, 48145, Münster, Deutschland
  
• 刊物主题：Pneumology/Respiratory System; Medicine/Public Health, general; Allergology; Internal Medicine; Infectious Diseases; Oncology;
• 出版者：Springer Berlin Heidelberg
• ISSN：1613-6055

文摘

Bronchopulmonary dysplasia (BPD) is additional oxygen demand reaching beyond the newborn period of 28 days. During the “old” BPD, structural changes in the lung occur because of a volutrauma and O₂ toxicity due to mechanical ventilation. However, the “new” BPD is characterised by a rarefication of alveolar structures because of an impaired differentiation owing to lacking growth factors. Pulmonary function diagnostics show a reduced functional residual capacity already in prematures with BPD. FEV1, MEF75-25, RCV and DLCO are significantly decreased in infancy and adulthood. Depending on stress, there is an increased development of chronic lung problems. Patients with BPD are jeopardised by infects of the respiratory tract, pulmonary arterial hypertension and exposition to tobacco smoke. Furthermore, the disease can lead to disorders of the neurological development and to psychological problems. Keywords Bronchopulmonary dysplasia Extremely premature Pulmonary hypertension Pulmonary atelectasis Hypoxia-inducible factor 1