Catalyst-free synthesis of dihydropyridine from barbituric acid in water

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• 作者：Najmadin Azizi (1) azizi@ccerci.ac.ir
  Akbar Mobinikhaledi (2)
  Alireza Khajeh Amiri (2) a_khajehamiri@yahoo.com
  Hossein Ghafuri (3)
• 关键词：Aldehydes – ; Barbituric acid – ; Dihydropyridine – ; Novel hydrogen bonding – ; Water chemistry
• 刊名：Research on Chemical Intermediates
• 出版年：2012
• 出版时间：November 2012
• 年：2012
• 卷：38
• 期：9
• 页码：2271-2275
• 全文大小：190.9 KB
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• 作者单位：1. Chemistry and Chemical Engineering Research Center of Iran, P.O. Box 14335-186, Tehran, Iran2. Department of Chemistry, Faculty of Sciences, Arak University, Arak, 38156-879 Iran3. Department of Chemistry, Payame Noor University, Damavand Branch, Tehran, Iran
• ISSN：1568-5675

文摘

An operationally simple, atom-economical, and green procedure has been developed for the synthesis of dihydropyridine derivatives by a simple condensation of barbituric acid, aldehyde, and ammonium acetate in water under catalyst-free conditions. Excellent yields and purity were obtained with only filtration and washing with hot water and ethanol.