Blockage of glycolysis by targeting PFKFB3 suppresses tumor growth and metastasis in head and neck squamous cell carcinoma

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• 作者：Hui-Min Li ; Jie-Gang Yang ; Zhuo-Jue Liu…
• 关键词：HNSCC ; Glycolysis ; PFKFB3 ; Metastasis ; Invadopodia ; Invasion
• 刊名：Journal of Experimental & Clinical Cancer Research
• 出版年：2017
• 出版时间：December 2017
• 年：2017
• 卷：36
• 期：1
• 全文大小：5975KB
• 刊物主题：Oncology; Cancer Research; Immunology; Apoptosis;
• 出版者：BioMed Central
• ISSN：1756-9966
• 卷排序：36

文摘

BackgroundMany cancers including head and neck squamous cell carcinoma (HNSCC) are characterized by a metabolic rewiring with increased glucose uptake and lactate production, termed as aerobic glycolysis. Targeting aerobic glycolysis presents a promising strategy for cancer therapy. This study investigates the therapeutic potential of glycolysis blockage by targeting phosphofructokinase-2/fructose-2, 6-bisphosphatase 3 (PFKFB3) in HNSCC.