Multi-district coronary tree involvement in a 17-year-old girl with Williams鈥揃euren syndrome

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• 作者：Tiziana Serena ; Enrico Valerio ; Biagio Castaldi ; Elena Reffo…
• 关键词：Williams鈥揃euren syndrome ; Myocardial infarction ; Supravalvular aortic stenosis ; Multi ; district coronary artery disease ; Pediatric cardiology
• 刊名：SpringerPlus
• 出版年：2015
• 出版时间：December 2015
• 年：2015
• 卷：4
• 期：1
• 全文大小：993KB
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• 作者单位：Tiziana Serena (1)
  Enrico Valerio (1)
  Biagio Castaldi (1)
  Elena Reffo (1)
  Ornella Milanesi (1)
  
  1. Pediatric Cardiology Unit, Department of Woman and Child Health, Medical School, University of Padua, Via Giustiniani, 3, 35128, Padua, Italy
  
• 刊物类别：Science, general;
• 刊物主题：Science, general;
• 出版者：Springer International Publishing
• ISSN：2193-1801

文摘

We describe a case of 17-year-old Chinese girl referred to our Pediatric Cardiology Unit for asthenia, reduced exercise tolerance, and dyspnea. Past medical history was relevant for multiple chest pain episodes in childhood and several syncopal episodes, for which the patient had been never evaluated. Clinical examination, electrocardiogram, and echocardiography were compatible with Williams鈥揃euren syndrome; such condition was later confirmed by genetic analysis. Cardiac magnetic resonance imaging showed transmural fibrosis of the apex with impaired left ventricular ejection fraction (29 %), severe stenosis of aortic sinotubular junction with left and right coronary ostia involvement; more importantly, the whole coronary artery tree beyond ostia was affected by multiple stenosis and aneurysmatic tracts. Ascending aorta proved hypoplastic, with post-stenotic dilation and multiple aneurysms. At the end of the diagnostic process, surgical risk was considered too high to proceed with the correction. The presented case is of educational value since it provides good iconographical illustration of diffuse, multiple-site coronary artery tree involvement, a rather rare co-morbidity in Williams鈥揃euren syndrome. Keywords Williams鈥揃euren syndrome Myocardial infarction Supravalvular aortic stenosis Multi-district coronary artery disease Pediatric cardiology