Soluble CD44 concentration in the serum and peritoneal fluid samples of patients with different stages of endometriosis

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• 作者：Farhad Mashayekhi ; Hadis Aryaee ; Ebrahim Mirzajani…
• 关键词：Soluble CD44 ; Serum ; Endometriosis
• 刊名：Archives of Gynecology and Obstetrics
• 出版年：2015
• 出版时间：September 2015
• 年：2015
• 卷：292
• 期：3
• 页码：641-645
• 全文大小：380 KB
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• 作者单位：Farhad Mashayekhi (1)
  Hadis Aryaee (2)
  Ebrahim Mirzajani (3)
  Ashraf Ale Yasin (4)
  Abdolsatar Fathi (5)
  
  1. Department of Biology, Faculty of Sciences, University of Guilan, 1914, Rasht, Iran
  2. Department of Cell and Molecular Biology, University of Guilan, University Campus 2, Rasht, Iran
  3. Faculty of Medicine, Cellular and Molecular Research Center, Guilan University of Medical Sciences, Rasht, Iran
  4. Tehran University of Medical Sciences, Tehran, Iran
  5. Azad University of Borujerd, Borujerd, Iran
  
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Gynecology
  Obstetrics and Perinatology
  Endocrinology
  Human Genetics
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1432-0711

文摘

Purpose Endometriosis is a gynecological disease defined by the histological presence of endometrial glands and stroma outside the uterine cavity, most commonly implanted over visceral and peritoneal surface within the female pelvis. CD44 is a membrane protein expressed by human endometrial cells, and it has been shown to promote the adhesion of endometrial cells. The aim of this study was to determine the levels of soluble CD44 (sCD44) in the serum and peritoneal fluid (PF) samples of patients with different stages of endometriosis. Methods 39 PF and serum samples from normal healthy and 130 samples from different stages of patients with endometriosis (33 cases of stage I, 38 stage II, 30 stage III and 29 stage IV) were included in this study. Total protein concentration (TPC) and the level of s-cMet in the serum were determined by Bio-Rad protein assay based on the Bradford dye procedure and enzyme-linked immunosorbent assay, respectively. Results No significant change in the TPC was seen in the serum of patients with endometriosis when compared to normal controls. Results obtained demonstrated that all serum and peritoneal fluid samples, presented sCD44 expression, whereas, starting from stages I to IV endometriosis, a significant increase of sCD44 expression was observed as compared to control group. Conclusions The results of this study show that a high expression of sCD44 is correlated with advanced stages of endometriosis. It is also concluded that the detection of serum and/or peritoneal fluid sCD44 may be useful in classifying endometriosis.