Butylidenephthalide antagonizes cromakalim-induced systolic pressure reduction in conscious normotensive rats

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• 作者：Chung-Hung Shih ; Yu-Jing Lin ; Chi-Ming Chen…
• 关键词：4 ; Aminopiridine ; ATP ; sensitive K+ channels ; Kv1 family of K+ channels ; Butylidenephthalide ; Conscious normotensive rats ; Cromakalim
• 刊名：BMC Complementary and Alternative Medicine
• 出版年：2015
• 出版时间：December 2015
• 年：2015
• 卷：15
• 期：1
• 全文大小：586 KB
• 刊物主题：Complementary & Alternative Medicine; Internal Medicine; Chiropractic Medicine;
• 出版者：BioMed Central
• ISSN：1472-6882

文摘

Background Butylidenephthalide (Bdph), a main constituent of Ligusticum chuanxiong Hort., was reported to have selective antianginal effect without changing blood pressure in conscious rat. Recently, we have observed that Bdph antagonized cromakalim, an ATP-dependent K+ channel opener, in guinea-pig trachea. Thus, we were interested in investigating whether Bdph at the dose without changing blood pressure antagonized cromakalim-induced systolic pressure reduction in conscious rats.