Monoamine Oxidase A (MAOA) and Catechol-O-Methyltransferase (COMT) Gene Polymorphisms Interact with Maternal Parenting in Association with Adolescent Reactive Aggression but not Proactive Aggressi

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Monoamine Oxidase A (MAOA) and Catechol-O-Methyltransferase (COMT) Gene Polymorphisms Interact with Maternal Parenting in Association with Adolescent Reactive Aggression but not Proactive Aggressi

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作者：Wenxin Zhang ; Cong Cao ; Meiping Wang ; Linqin Ji…
关键词：MAOA gene ; COMT gene ; Reactive aggression ; Proactive aggression ; Differential susceptibility
刊名：Journal of Youth and Adolescence
出版年：2016
出版时间：April 2016
年：2016
卷：45
期：4
页码：812-829
全文大小：804 KB
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作者单位：Wenxin Zhang (1)
Cong Cao (1)
Meiping Wang (1)
Linqin Ji (1)
Yanmiao Cao (1)

1. Department of Psychology, Shandong Normal University, No. 88 East Wenhua Road, Jinan, 250014, Shandong Province, China
刊物类别：Behavioral Science
刊物主题：Psychology
Child and School Psychology
Clinical Psychology
Health Psychology
Law and Psychology
History of Psychology
Psychology
出版者：Springer Netherlands
ISSN：1573-6601

文摘

To date, whether and how gene-environment (G × E) interactions operate differently across distinct subtypes of aggression remains untested. More recently, in contrast with the diathesis-stress hypothesis, an alternative hypothesis of differential susceptibility proposes that individuals could be differentially susceptible to environments depending on their genotypes in a “for better and for worse” manner. The current study examined interactions between monoamine oxidase A (MAOA) T941G and catechol-O-methyltransferase (COMT) Val158Met polymorphisms with maternal parenting on two types of aggression: reactive and proactive. Moreover, whether these potential G × E interactions would be consistent with the diathesis-stress versus the differential susceptibility hypothesis was tested. Within the sample of 1399 Chinese Han adolescents (47.2 % girls, M _age = 12.32 years, SD = 0.50), MAOA and COMT genes both interacted with positive parenting in their associations with reactive but not proactive aggression. Adolescents with T alleles/TT homozygotes of MAOA gene or Met alleles of COMT gene exhibited more reactive aggression when exposed to low positive parenting, but less reactive aggression when exposed to high positive parenting. These findings provide the first evidence for distinct G × E interaction effects on reactive versus proactive aggression and lend further support for the differential susceptibility hypothesis.