We present a case of coronary artery disease with intermediate stenosis in the proximal left anterior descending artery, which was evaluated using multiple functional modalities. FFRCT demonstrated a significant perfusion abnormality in the LAD, and the value of FFRCT (0.68) was similar to the value measured by invasive FFR (0.67). However, the other modalities gave discrepant results. In particular, perfusion scintigraphy with thallium showed no evidence of an inducible perfusion abnormality in the LAD territory. The patient was treated by PCI for two tandem lesions in the LAD. FFRCT may have potential as a default noninvasive method for assessment of coronary anatomy and physiology.
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