Superoxidase dismutase (SOD) topical use in oncologic patients: treatment of acute cutaneous toxicity secondary to radiotherapy

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• 作者：álvaro Manzanas García (1)
  María Concepción López Carrizosa (2)
  Carmen Vallejo Oca?a (2)
  Pilar Samper Ots (2)
  José María Delgado Pérez (2)
  Emilia Carretero Accame (1)
  Pilar Gómez-Serranillos (1)
  Luis de la Morena del Valle (1)
  
• 关键词：Superoxide dismutase ; Radiodermatitis ; Orgotein ; Topical route
• 刊名：Clinical and Translational Oncology
• 出版年：2008
• 出版时间：March 2008
• 年：2008
• 卷：10
• 期：3
• 页码：163-167
• 全文大小：130KB
• 参考文献：1. Nakano T, Oka K, Taniguchi N (1996) Manganese superoxide dismutase expression correlates with p53 status and local recurrence of cervical carcinoma treated with radiation therapy. Cancer Res 56:2771-775
  2. Buell MG, Hording RK (1989) Proinflammatory effects of local abdominal irradiation on rat GI tract. Dig Dis Sci 34:390-99 CrossRef
  3. De AK, Rajan RR, Krishnamoorthy L et al (1995) Oxidative stress in radiation-induced interstitial pneumonitis in the rat. Int J Radiat Biol 68:405-09 CrossRef
  4. Epperly M, Bray J, Kraeger S et al (1998) Prevention of late effects of irradiation lung damage by manganese superoxide dismutase gene therapy. Gen Ther 5:196-08 CrossRef
  5. McCord JM, Fridovich I (1969) Superoxide dismutase: an enzymatic function for erythrocuprein (hemocuprein). J Biol Chem 244:6049-055
  6. Esco R, Valencia J, Bascon N et al (2003) Prevención de toxicidad rectal tardía radioinducida. Estudio randomizado. Rev Oncología 5:190
  7. Esco R, Valencia J, Bascon N et al (2003) Estudio randomizado de prevención de toxicidad radioinducida tardía pélvica mediante Ontosein?. Rev Oncología 5:190
  8. Valencia J, Polo S, Velilla C et al (2001) Impacto del uso de orgoteina en la prevención de esofagitis por irradiación en el carcinoma microcítico pulmonar. Rev Oncología 3:204
  9. Valencia J, Polo S, Bascon N et al (2000) Orgoteina asociada a radioterapia en cancer de cabeza y cuello. Control de la toxicidad. Rev Oncología 2:137
  10. Edsmyr F, Menander Huber KB (1981) Orgotein efficacy in ameliorating side effects due to radiation therapy. Eur J Rheum Inflamm 4:228-36
  11. Edsmyr F, Huber W, Menander KB (1976) Orgotein efficacy in ameliorating side effects due to radiation therapy. Double-blind, placebo-controlled trial in patients with bladder tumors. Curr Ther Res 19:198-11
  12. Maberger H, Hubert W, Menandert Hubert KB, Bartsch G (1981) Orgotein: a new drug for the treatment of radiation cystitis. Eur J Rheum Inflamm 4:244-49
  13. Menander Huber KB, Edsmyr F, Huber W (1980) Orgotein efficacy in ameliorating side effects due to radiation therapy. Scand J Urol Nephrol 55:219-24
  14. Vaca JM, Vegas M, Merino R (1997) Epidural orgotein in failed back syndrome. II Congress of the European Federation of IAPS 1997. Barcelona, Spain
  15. Ruiz A, Gil R (1999) Tratamiento del dolor mediante administración intradérmica de una solución compuesta por anestésico local+antiinflamatorio+analgésico. IV congreso de la SED, Málaga, Spain
  16. Reig E (1994) Sistemas de infusión de fármacos en el tratamiento del dolor. Rev Soc Esp Dolor 1:14-0
  17. Rodríguez-López M, Camba A, Contreras D, Torres LM (2003) Multicenter clinical trial of epidural orgotein versus placebo in patients with chronic intractable spinal pain. Pain Clin 15:7-5 CrossRef
  18. Rubin P, Constine LS, Fajardo LF et al (1995) Overview: late effects of normal tissues (LENT) scoring system. Int J Radiat Oncol Biol Phys 3:1041-042
  19. Cox JD, Stetz JA, Pajak TF (1995) Toxicity criteria of radiation therapy oncology group (RTOG) and European Organization for Research and Treatment of Cancer (EORTC). Int J Radiat Oncol Biol Phys 31:1341-346
  20. Fuentes R, Canals E, Vayreda J (2003) Tratamientos de soporte en oncología radioterápica. Servicio de Oncología Radioterápica. Institut Catalá d’Oncologia, Girona (9):40-3
  21. Sanchiz F, Millá A (1996) Prevention with orgotein of radioinduced secondary effects in patients with head and neck tumours. VIII Biennial Meeting International Society for Free Radical Research, Paris, France
  22. Perderau B, Campana F, Vilcoq JR et al (1994) Superoxyde dismutase (Cu/Zn) en application cutanée dans le traitment des fibrose radioinduites. Bull Cancer 81:659-69
  23. Benyahia B, Campana F, Perderau B et al (1996) Effects of superoxide dismutase topical treatment on human skin radiofibrosis: a pathological study. Breast 5:75-1 CrossRef
  24. Campana F, Zervoudis S, Perdereau B et al (2004) Topical superoxide dismutase reduces post-irradiation breast cancer fibrosis. J Cel Mol Med 8:109-16 CrossRef
  25. Valencia J, Bascon N, Polo S et al (2000) Orgotein impact on radiotherapy acute side effects in head and neck cancer. Radiother Oncol 56:411
  26. Valencia J, Velilla C, Urpegui A et al (2002) The efficacy of orgotein in the treatment of acute toxicity due to radiotherapy on head and neck tumors. Tumori 88:385-89
  
• 作者单位：álvaro Manzanas García (1)
  María Concepción López Carrizosa (2)
  Carmen Vallejo Oca?a (2)
  Pilar Samper Ots (2)
  José María Delgado Pérez (2)
  Emilia Carretero Accame (1)
  Pilar Gómez-Serranillos (1)
  Luis de la Morena del Valle (1)
  
  1. Departamento de Farmacología Facultad de Farmacia, Universidad Complutense de Madrid, Madrid, Spain
  2. Servicio de Radioterapia Oncológica, Hospital Central de la Defensa, Madrid, Spain
  

文摘

Objective The objective of this study is to evaluate the efficiency of SOD applied topically in oncologic patients affected by acute radiodermatitis. Materials and method This study includes 57 patients who showed a dermatitis grade 2 or superior; they were administered SOD ointment b.i.d. (40 mg, weekly) and follow-up continued for 12 weeks. Results At the end of radiotherapy, 77.1% of the patients ameliorated completely or partially, and at the end of the 12-week period 100% of patients were free of toxicity. No acute toxicity relapses were reported. Response time reduced during radiotherapy, as well as the treatment time at the end of it. Conclusions The employment of SOD topically is efficient in the treatment of radiodermatitis, which is an acute side effect of radiotherapy.