Use of α1-microglobulin for diagnosing chronic interstitial nephropathy

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• 作者：Nicolas R. Robles (1) (3)
  Juan Lopez-Gomez (2)
  Guadalupe Garcia-Pino (1)
  Flavio Ferreira (1)
  Raul Alvarado (1)
  Emilio Sanchez-Casado (1)
  Juan J. Cubero (1)
  
• 关键词：α1 ; Microglobulin ; Interstitial nephritis ; Diagnosis
• 刊名：Clinical and Experimental Medicine
• 出版年：2014
• 出版时间：August 2014
• 年：2014
• 卷：14
• 期：3
• 页码：315-320
• 全文大小：342 KB
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• 作者单位：Nicolas R. Robles (1) (3)
  Juan Lopez-Gomez (2)
  Guadalupe Garcia-Pino (1)
  Flavio Ferreira (1)
  Raul Alvarado (1)
  Emilio Sanchez-Casado (1)
  Juan J. Cubero (1)
  
  1. Servicio de Nefrología, Hospital Infanta Cristina, Badajoz, Spain
  3. Unidad de Hipertensión Arterial, Hospital Infanta Cristina, Carretera de Portugal s/n, 06080, Badajoz, Spain
  2. Servicio de Análisis Clinicos, Hospital Infanta Cristina, Badajoz, Spain
  
• ISSN：1591-9528

文摘

α1-Microglobulin (α1M) is a low molecular weight protein and has been best characterized for detecting acute lesions of proximal tubules (Bonventre in Contrib Nephrol 156:213-19, 2007). This study has tried to evaluate the use of α1M for the differential diagnosis of chronic interstitial nephropathy. 145 patients were recruited [81 men and 64 women, mean age 61.8?±?16.7?years, 64.8?% have an estimated glomerular filtration (GFR) n?=?17). Patients in GN group had the highest α1M excretion (15.05?mg/24?h). When the α1M/albuminuria rates were calculated, the CIN group had the highest rate (1.03?mg/mg) and the GN group had the lowest rate (0.04?mg/mg) (p?