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Comparison of the effects of bimatoprost and a fixed combination of latanoprost and timolol on 24-hour blood and ocular perfusion pressures: the results of a randomized trial
- 作者:Luca Rossetti (5)
Matteo Sacchi (5) Costas H Karabatsas (6) Fotis Topouzis (7) Michele Vetrugno (8) Marco Centofanti (9) Andreas Boehm (10) Christian Vorwerk (11) David Goldblum (12) Paolo Fogagnolo (5)
5. Clinica Oculistica ; Dipartimento di Medicina ; Chirurgia e Odontoiatria ; Università di Milano ; Ospedale San Paolo ; Via di Rudinì 8 ; 20142 ; Milan ; Italy 6. Department of Ophthalmology ; University of Thessaly School of Medicine ; Larissa ; Greece 7. Department of Ophthalmology ; School of Medicine ; Aristotle University of Thessaloniki ; American Hellenic Educational Progressive Association (AHEPA) Hospital ; Thessaloniki ; Greece 8. Anthea Hospital ; GVM Care and Research ; Bari ; Italy 9. DSCMT Università di Roma ‘Tor Vergata- IRCCS Fondazione G.B. Bietti ; Rome ; Italy 10. University Hospital Carl Gustav Carus Dresden ; Technical University Dresden ; Dresden ; Germany 11. Augenklinik der Otto von Guericke Universit?t Magdeburg ; Magdeburg ; Germany 12. Department of Ophthalmology ; University Hospital Basel ; University Basel ; Basel ; Switzerland
- 刊名:BMC Ophthalmology
- 出版年:2015
- 出版时间:December 2015
- 年:2015
- 卷:15
- 期:1
- 参考文献:1. Casson RJ, Chidlow G, Wood JP, Crowston JG, Goldberg I: Definition of glaucoma: clinical and experimental concepts. / Clin Exp Ophthalmol 2012, 40:341-. 10.1111/j.1442-9071.2012.02773.x CrossRef
2. De Moraes CG, Demirel S, Gardiner SK, Liebmann JM, Cioffi GA, Ritch R, / et al.: Effect of treatment on the rate of visual field change in the ocular hypertension treatment study observation group. / Invest Ophthalmol Vis Sci 2012, 53:1704-. 10.1167/iovs.11-8186 CrossRef 3. Leske MC, Heijl A, Hyman L, Bengtsson B, Dong L, Yang Z, / et al.: Predictors of long-term progression in the early manifest glaucoma trial. / Ophthalmology 2007, 114:1965-2. 10.1016/j.ophtha.2007.03.016 CrossRef 4. Maier PC, Funk J, Schwarzer G, Antes G, Falck-Ytter YT: Treatment of ocular hypertension and open angle glaucoma: meta-analysis of randomised controlled trials. / BMJ 2005,331(7509):134. 10.1136/bmj.38506.594977.E0 CrossRef 5. Zheng Y, Wong TY, Mitchell P, Friedman DS, He M, Aung T: Distribution of ocular perfusion pressure and its relationship with open-angle glaucoma: the singapore malay eye study. / Invest Ophthalmol Vis Sci 2010, 51:3399-04. 10.1167/iovs.09-4867 CrossRef 6. Memarzadeh F, Ying-Lai M, Chung J, Azen SP, Varma R, Los Angeles Latino Eye Study Group: Blood pressure, perfusion pressure, and open-angle glaucoma: the Los Angeles Latino Eye Study. / Invest Ophthalmol Vis Sci 2010, 51:2872-. 10.1167/iovs.08-2956 CrossRef 7. Leske MC: Ocular perfusion pressure and glaucoma: clinical trial and epidemiologic findings. / Curr Opin Ophthalmol 2009, 20:73-. 10.1097/ICU.0b013e32831eef82 CrossRef 8. Hulsman CA, Vingerling JR, Hofman A, Witteman JC, de Jong PT: Blood pressure, arterial stiffness, and open-angle glaucoma: the Rotterdam study. / Arch Ophthalmol 2007, 125:805-2. 10.1001/archopht.125.6.805 CrossRef 9. Bonomi L, Marchini G, Marraffa M, Bernardi P, Morbio R, Varotto A: Vascular risk factors for primary open angle glaucoma: the Egna-Neumarkt Study. / Ophthalmology 2000, 107:1287-3. 10.1016/S0161-6420(00)00138-X CrossRef 10. Leske MC, Wu SY, Hennis A, Honkanen R, Nemesure B, BESs Study Group: Risk factors for incident open-angle glaucoma: the Barbados Eye Studies. / Ophthalmology 2008, 115:85-3. 10.1016/j.ophtha.2007.03.017 CrossRef 11. De Moraes CG, Liebmann JM, Greenfield DS, Gardiner SK, Ritch R, Krupin T, / et al.: Risk factors for visual field progression in the low-pressure glaucoma treatment study. / Am J Ophthalmol 2012, 154:702-1. 10.1016/j.ajo.2012.04.015 CrossRef 12. Okumura Y, Yuki K, Tsubota K: Low diastolic blood pressure is associated with the progression of normal-tension glaucoma. / Ophthalmologica 2012, 228: - 刊物主题:Ophthalmology;
- 出版者:BioMed Central
- ISSN:1471-2415
文摘
Background To compare the effect of bimatoprost and the fixed combination latanoprost-timolol (LTFC) on 24-hour systolic (SBP) and diastolic (DBP) blood pressure and on 24-hour ocular perfusion pressure (OPP). Methods 200 patients with glaucoma or ocular hypertension, controlled on the unfixed combination of latanoprost and timolol or eligible for dual therapy being not being fully controlled on monotherapy were enrolled in a randomized, double-masked, placebo-controlled, multicentre clinical trial. They were randomized to LTFC (8 a.m.) or bimatoprost (8 p.m.) and received 24-hour IOP curve at baseline, 6 and 12 weeks (supine and sitting position IOPs were recorded at 8 p.m., midnight, 5 a.m., 8a.m., noon and 4 p.m.). Holter 24-hour blood pressure curve was obtained between weeks 2 and 12. SBP, DBP, OPP were calculated and compared with ANOVA. Rates of diastolic OPP (DPP) ?0, ?0, ?0 mmHg in the 2 groups were calculated and compared using Fisher’s test. Results Mean baseline SBP and DBP were 136.5?±-8.3 vs 134.2?±-0.1 mmHg (p--.1) and 79.1?±-0.2 vs 78.2?±-0.1 mmHg (p--.4) in the bimatoprost and LTFC groups respectively. Holter SBP was significantly higher for bimatoprost (135.1 mmHg vs 128.1 mmHg, p--.04), while no statistically significant difference in DBP was found. DPP was similar in the 2 groups, and proportions of patients with at least one value of the 24-hour curve ?0, ?0, ?0 mmHg were 94%, 86%, 41% respectively. Conclusions Bimatoprost and LTFC had similar DBPs and OPPs; SBP was significantly lower with LTFC. In this study, the percentage of “dippers-was considerably higher than the one described in previous studies on the role of perfusion pressure in glaucoma. Trial registration NCT02154217, May 21, 2014.
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