ACCORDION MIND: results of the observational extension of the ACCORD MIND randomised trial

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• 作者：Anne M. Murray ; Fang-Chi Hsu ; Jeff D. Williamson ; R. Nick Bryan…
• 关键词：Abnormal white matter volume ; Brain MRI ; Cognitive impairment ; Total brain volume ; Type 2 diabetes
• 刊名：Diabetologia
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：60
• 期：1
• 页码：69-80
• 全文大小：
• 刊物类别：Medicine
• 刊物主题：Internal Medicine; Metabolic Diseases; Human Physiology;
• 出版者：Springer Berlin Heidelberg
• ISSN：1432-0428
• 卷排序：60

文摘

Aims/hypothesisThe Memory in Diabetes (MIND) substudy of the Action to Control Cardiovascular Risk in Diabetes (ACCORD) study, a double 2x2 factorial parallel-group randomised clinical trial, tested whether intensive compared with standard management of hyperglycaemia, BP or lipid levels reduced cognitive decline and brain atrophy in 2977 people with type 2 diabetes. We describe the results of the observational extension study, ACCORDION MIND (ClinicalTrials.gov registration no. NCT00182910), which aimed to measure the long-term effects of the three ACCORD interventions on cognitive and brain structure outcomes approximately 4 years after the trial ended.