Binarization of enhanced depth imaging optical coherence tomographic images of an eye with Wyburn-Mason syndrome: a case report

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• 作者：Akiko Iwata ; Yoshinori Mitamura ; Masanori Niki ; Kentaro Semba…
• 关键词：Binarization ; Choroidal structure ; Enhanced depth imaging optical coherence tomography ; Fluorescein angiography ; Wyburn ; Mason syndrome
• 刊名：BMC Ophthalmology
• 出版年：2015
• 出版时间：December 2015
• 年：2015
• 卷：15
• 期：1
• 全文大小：1,767 KB
• 参考文献：1. Fileta, JB, Bennett, TJ, Quillen, DA (2014) Wyburn-Mason Syndrome. JAMA Ophthalmol 132: pp. 805 CrossRef
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• 刊物主题：Ophthalmology;
• 出版者：BioMed Central
• ISSN：1471-2415

文摘

Background To report a thicker choroid and larger choroidal luminal area in an eye with Wyburn-Mason syndrome. To the best of our knowledge, this is the first report demonstrating an increase in the choroidal thickness and the luminal area in a case of Wyburn-Mason syndrome. In addition, we report the changing appearance of retinal arteriovenous malformations over a 16-year period. Case presentation A 27-year-old woman, who was diagnosed with Wyburn-Mason syndrome at age 11?years, visited our clinic. Her best-corrected visual acuity was 20/12.5 in the right eye and light perception in the left eye. Severely dilated, tortuous vascular loops were distributed from the optic disc over all four quadrants of the left fundus. The vascular loops in some areas were more dilated and tortuous than 16?years earlier. Optical coherence tomography (OCT) showed retinal edema with cystic changes and enlarged choroidal vessel lumens in the left eye. The subfoveal choroidal thickness was manually measured by the caliper function in the enhanced depth imaging OCT (EDI-OCT) images. Binarization of the EDI-OCT images was performed with publicly accessible ImageJ software. The examined area of the subfoveal choroid was 1,500?μm wide, and the dark areas representing the luminal areas were traced by the Niblack method. After determining the distance of each pixel, the luminal area was automatically calculated. The subfoveal choroidal thickness was 250?μm in the right eye and 462?μm in the left eye. The luminal area of the 1,500-μm-wide subfoveal choroid was computed to be 307,165.6?μm2 in the right eye and 545,780.7?μm2 in the left eye. Conclusions The EDI-OCT images showed a thicker choroid, and binarization of the EDI-OCT images showed that the luminal areas were significantly larger in the affected eye, suggesting a dilatation of the choroidal vessels. The results demonstrated that conversion of EDI-OCT images to binary images was a useful method to quantify the choroidal structure.