Circulation of Coxsackievirus A6 in hand-foot-mouth disease in Guangzhou, 2010-2012

详细信息    查看全文

• 作者：Biao Di ; Ying Zhang ; Huaping Xie ; Xiaoquan Li ; Chun Chen ; Peng Ding…
• 关键词：Hand ; Foot and mouth disease ; Coxsackievirus A6 ; Epidemiologic feature ; Molecular analysis
• 刊名：Virology Journal
• 出版年：2014
• 出版时间：December 2014
• 年：2014
• 卷：11
• 期：1
• 全文大小：1,947 KB
• 参考文献：1. Robinson, CR, Doane, FW, Rhodes, AJ (1958) Report of an outbreak of febrile illness with pharyngeal lesions and exanthema: Toronto, summer 1957- isolation of group A Coxsackie virus. Can Med Assoc J 79: pp. 615-621
  2. Kennett, ML, Birch, CJ, Lewis, FA, Yung, AP, Locamini, SA, Gust, ID (1974) Enterovirus type 71 infection in Melbourne. Bull World Health Organ 51: pp. 609-615
  3. Eggertson, L (2012) Infectious disease experts monitor outbreaks of enterovirus 71 in Asia. CMA J 184: pp. E781-E782 CrossRef
  4. Zhu, J, Luo, Z, Wang, J, Xu, Z, Chen, H, Fan, D, Gao, N, Ping, G, Zhou, Z, Zhang, Y, An, J (2013) Phylogenetic analysis of enterovirus 71 circulating in Beijing, China from 2007 to 2009. PLoS One 8: pp. e56318 CrossRef
  5. Sun, LM, Zheng, HY, Zheng, HZ, Xue, G, He, JF, Cuan, DW, Kang, ML, Liu, Z, Ke, CW, Li, JS, Liu, L, Guo, RN, Hiromu, Y, Lin, JY (2011) An enterovirus 71 epidemic in Guangdong Province of China, 2008: epidemiological, clinical, and virogenic manifestations. Jpn J Infect Dis 64: pp. 13-18
  6. Zhang, Y, Zhu, Z, Yang, W, Ren, J, Tan, X, Wang, Y, Mao, N, Xu, S, Zhu, S, Cui, A, Zhang, Y, Yan, D, Li, Q, Dong, X, Zhang, J, Zhao, Y, Wan, J, Feng, Z, Sun, J, Wang, S, Li, D, Xu, W (2010) An emerging recombinant human enterovirus 71 responsible for the 2008 outbreak of hand foot and mouth disease in Fuyang city of China. Virol J 7: pp. 94 CrossRef
  7. Wang, Y, Feng, Z, Yang, Y, Self, S, Gao, Y, Longini, IM, Wakefield, J, Zhang, J, Wang, L, Chen, X, Yao, L, Stanaway, JD, Wang, Z, Yang, W (2011) Hand, foot, and mouth disease in China: patterns of spread and transmissibility during 2008-009. Epidemiology 22: pp. 781-792 CrossRef
  8. Li, L, He, Y, Yang, H, Zhu, J, Xu, X, Dong, J, Zhu, YF, Jin, Q (2005) Genetic characteristics of human enterovirus 71 and coxsackievirus A16 circulating from 1999 to 2004 in Shenzhen, People’s Republic of China. J Clin Microbiol 43: pp. 3835-3839 CrossRef
  9. Liang, HY, Kang, Y, Tao, X, Li, MX, Luo, L (2011) [Dynamic analysis of the epidemiological characteristics of hand-foot-mouth disease during 2008-011, Guangzhou]. J Tropi Medici 11: pp. 1410-1413
  10. Lu, QB, Zhang, XA, Wo, Y, Xu, HM, Li, XJ, Wang, XJ, Ding, SJ, Chen, XD, He, C (2012) Circulation of Coxsackievirus A10 and A6 in hand-foot-mouth disease in China, 2009-011. PLoS One 7: pp. p.e52073 CrossRef
  11. Davia, JL, Bel, PH, Ninet, VZ, Bracho, MA, González-Candelas, F, Salaza, A, Gobernado, M, Bosch, IF (2011) Onychomadesis outbreak in Valencia, Spain associated with hand, foot, and mouth disease caused by enteroviruses. Pediatr Dermatol 28: pp. 1-5 CrossRef
  12. Mirand, A, Henquell, C, Archimbaud, C, Ughetto, S, Antona, D, Bailly, JL, Peigue-Lafeuille, H (2012) Outbreak of hand, foot and mouth disease/herpangina associated with coxsackievirus A6 and A10 infections in 2010, France: a large citywide, prospective observational study. Clin Microbiol Infect 18: pp. E110-E118 CrossRef
  13. Flett, K, Youngster, I, Huang, J, McAdam, A, Sandora, TJ, Rennick, M, Smole, S, Rogers, SL, Nix, WA, Oberste, MS, Gellis, S, Ahmed, AA (2012) Hand, foot, and mouth disease caused by coxsackievirus A6. Emerg Infect Dis 18: pp. 1702-1704
  Severe hand, foot, and mouth disease associated with coxsackievirus A6 - Alabama, Connecticut, California, and Nevada, November 2011-February 2012. Morb Mortal Wkly Rep 61: pp. 213-214
  14. Ben-Chetrit, E, Wiener-Well, Y, Shulman, LM, Cohen, MJ, Elinav, H, Sofer, D, Feldman, I, Marva, E, Wolf, DG (2014) Coxsackievirus A6-related hand foot and mouth disease: skin manifestations in a cluster of adult patients. J Clin Virol 59: pp. 201-203 CrossRef
  15. Leitch, EC, Harvala, H, Robertson, I, Ubillos, I, Templeton, K, Simmonds, P (2009) Direct identification of human enterovirus serotypes in cerebrospinal fluid by amplification and sequencing o
• 刊物主题：Virology;
• 出版者：BioMed Central
• ISSN：1743-422X

文摘

Background Hand, foot and mouth disease (HFMD) is usually caused by Enterovirus 71(EV71), and Coxsackievirus A16 (CV-A16) in Guangzhou, the biggest city of South China. However, Coxsackievirus A6 (CV-A6) were observed increased dramatically from 2010-012. Methods In order to understand and to describe the epidemiologic and genetic characteristics of CV-A6, specimens of 5482 suspected HFMD cases were collected and examined by real-time fluorescence PCR. All samples positive for enteroviruses were analyzed by descriptive statistics. Phylogenetic analysis of CV-A6 based on the VP1 sequences was performed to investigate molecular and evolutionary characteristics. Results Coxsackievirus A6 increased dramatically from 9.04% in 2010 to 23.21% in 2012 and became one of the main causative agents of HFMD in Guangzhou. CV-A6 attack rates were highest in one to two year olds (33.14%). Typical clinic symptoms of CV-A6 HFMD include fever (589/720, 81.81%), maculopopular rash and vesicular exanthema around the perioral area (408/720, 56.66%), intraoral (545/720, 75.69%), the buttock (395/720, 54.86%), the trunk (244/720, 33.89%), the knee (188/720, 26.11%), and the dorsal aspects of hands (437/720, 60.69%). Phylogenetic analysis showed the CV-A6 isolates in this study belonged to Cluster A1 and were similar to those found in Shanghai in 2011 and 2012 (JX495148, KC414735), Shenzhen in 2011 (JX473394), Japan in 2011 (AB649243, AB649246), France in 2010(HE572928), Thailand in 2012(JX556564) and Israel in 2012 and 2013(.KF991010, KF991012).