Facile method for the synthesis of 2,3-dihydroquinazolin-4(1H)-ones catalyzed by SiO₂–H₃PW₁₂O₄₀ in water

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• 作者：Heshmatollah Alinezhad ; Elham Soleymani…
• 关键词：2 ; 3 ; Dihydroquinazolin ; 4(1H) ; one ; SiO2–H3PW12O40 ; 2 ; Aminobenzamide ; Heterogeneous catalyst
• 刊名：Research on Chemical Intermediates
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：43
• 期：1
• 页码：457-466
• 全文大小：
• 刊物类别：Chemistry and Materials Science
• 刊物主题：Catalysis; Physical Chemistry; Inorganic Chemistry;
• 出版者：Springer Netherlands
• ISSN：1568-5675
• 卷排序：43

文摘

The 12-tungstophosphoric acid supported on silica gel (PW/SiO₂) exhibits excellent activity in the synthesis of 2,3-dihydroquinazolin-4(1H)-ones by cyclocondensation reaction of 2-aminobenzamide with carbonyl compounds in water under reflux conditions. The desired products have been obtained in short reaction times in high yields. Our method has been successfully applied for both aldehydes and ketones (aromatic and aliphatic). Easy recovery and reusable catalyst, easy work-up and avoidance of using harmful organic solvents are the major advantages of our method in comparison to existing methods.