The Functions of Antioxidants and Heat Shock Proteins Are Altered in the Immune Organs of Selenium-Deficient Broiler Chickens

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The Functions of Antioxidants and Heat Shock Proteins Are Altered in the Immune Organs of Selenium-Deficient Broiler Chickens

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作者：Zijiang Yang ; Ci Liu ; Weijia Zheng ; Xiaohua Teng…
关键词：Selenium ; Broiler chick ; Immune organs ; Heat shock proteins ; Oxidative stress
刊名：Biological Trace Element Research
出版年：2016
出版时间：February 2016
年：2016
卷：169
期：2
页码：341-351
全文大小：13,111 KB
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作者单位：Zijiang Yang (1)
Ci Liu (1)
Weijia Zheng (1)
Xiaohua Teng (2)
Shu Li (1)

1. College of Veterinary Medicine, Northeast Agricultural University, Harbin, 150030, People’s Republic of China
2. College of Animal Science and Technology, Northeast Agricultural University, Harbin, 150030, People’s Republic of China
刊物主题：Biochemistry, general; Biotechnology; Nutrition; Oncology;
出版者：Springer US
ISSN：1559-0720

文摘

Despite increasing evidence indicating the essential involvement of selenium (Se) in the immune system, the effect of Se deficiency on the regulation of oxidative stress and heat shock proteins (Hsps) in broiler chickens is still unclear. In the present study, we established an exudative diathesis (ED) broiler chicken model caused by Se deficiency. We then analyzed histological observations and detected the expression levels of Hsps and antioxidant indexes in immune tissues. The antioxidant function declined remarkably, and most of the Hsp expression levels increased significantly in the spleen, thymus, and bursa of Fabricius of the broiler chicks with ED (except the messenger RNA (mRNA) levels of Hsp27, Hsp40, and Hsp70, which decreased in thymus tissues from the treatment groups); therefore, constitutive oxidation resistance and higher Hsps in broiler chicks with ED caused defects in immune organ morphology and function, as evidenced by abnormal histological structures: red pulp broadening and lymphocytes in the cortex and medulla of the thymic lobule decreased distinctly and distributed loosely. These results underscore the importance of Se in establishing an immune organ microenvironment conducive to normal function. Keywords Selenium Broiler chick Immune organs Heat shock proteins Oxidative stress