Knockdown of STIM1 Improves Neuronal Survival After Traumatic Neuronal Injury Through Regulating mGluR1-Dependent Ca2+ Signaling in Mouse Cortical Neurons

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• 作者：Peng-Fei Hou (1) (2)
  Zhan-Hui Liu (2)
  Nan Li (1) (3)
  Wen-Jia Cheng (4)
  Shi-Wen Guo (1)
  
  1. Department of Neurosurgery ; The First Affiliated Hospital of Xi鈥檃n Jiaotong University ; 277 West Yanta Road ; Xi鈥檃n ; 710061 ; Shaanxi ; China
  2. Department of Neurosurgery ; Ninth Hospital of Xi鈥檃n ; Xi鈥檃n ; 710054 ; Shaanxi ; China
  3. Department of Neurosurgery ; Xi鈥檃n Chidren鈥檚 Hospital ; Xi鈥檃n ; 710043 ; Shaanxi ; China
  4. Department of Pathology ; Ninth Hospital of Xi鈥檃n ; Xi鈥檃n ; 710054 ; Shaanxi ; China
  
• 关键词：Traumatic brain injury ; STIM1 ; mGluR1 ; Endoplasmic reticulum
• 刊名：Cellular and Molecular Neurobiology
• 出版年：2015
• 出版时间：March 2015
• 年：2015
• 卷：35
• 期：2
• 页码：283-292
• 全文大小：1,251 KB
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• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Biomedicine
  Neurosciences
  Animal Anatomy, Morphology and Histology
  
• 出版者：Springer Netherlands
• ISSN：1573-6830

文摘

Activation of glutamate receptors and followed increase of intracellular calcium concentration is a key pathological mechanism involved in secondary neuronal injury after traumatic brain injury (TBI). Stromal interaction molecule (STIM) proteins are considered to be important players in regulating neuronal Ca2+ homeostasis under normal aging and pathological conditions. Here, we investigated the role of STIM1 in regulating metabotropic glutamate receptor 1 (mGluR1)-related Ca2+ signaling and neuronal survival by using an in vitro traumatic neuronal injury (TNI) model. The expression of STIM1 was significantly increased at both mRNA and protein levels after TNI. Down-regulation of STIM1 by specific small interfere RNA significantly preserved neuronal viability, decreased lactate dehydrogenase release, and inhibited apoptotic cell death after traumatic injury. Moreover, knockdown of STIM1 significantly alleviated the mGluR1-related increase of cytoplasmic Ca2+ levels after TNI. By analyzing Ca2+ imaging in Ca2+-free conditions, we demonstrated that the mGluR1-dependent inositol trisphosphate receptor and/or ryanodine receptor-mediated Ca2+ release from the endoplasmic reticulum after TNI is strongly attenuated in the absence of STIM1. Together, our results demonstrate that in the mammalian nervous system, STIM1 is a key regulator of mGluR1-dependent Ca2+ signaling and knockdown of STIM1 might be an effective intervention target in TBI.