Evaluation of bone-seeking novel radiotracer ⁶⁸Ga-NO2AP-Bisphosphonate for the detection of skeletal metastases in carcinoma breast

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• 作者：Averilicia Passah ; Madhavi Tripathi…
• 关键词：Breast cancer ; Positron emission tomography ; 18F ; Sodium Fluoride ; 68Ga ; 1 ; 4 ; 7 ; triazacyclonone ; 1 ; 4 ; diacetic acid
• 刊名：European Journal of Nuclear Medicine and Molecular Imaging
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：44
• 期：1
• 页码：41-49
• 全文大小：
• 刊物类别：Medicine
• 刊物主题：Nuclear Medicine; Imaging / Radiology; Orthopedics; Cardiology; Oncology;
• 出版者：Springer Berlin Heidelberg
• ISSN：1619-7089
• 卷排序：44

文摘

PurposeThe successful labelling of bisphosphonates (BP) with 68Ga using macrocyclic chelators such as the based triazacyclononane (NO2AP) is a step forward in the in-house availability of a novel bone-seeking PET radiopharmaceutical with dual advantage of PET/CT imaging and generator production. In this study, we compared the novel generator-based skeletal radiotracer 68Ga-1,4,7-triazacyclonone-1,4-diacetic acid (68Ga-NO2AP-BP) with sodium fluoride (18F-NaF) for the detection of skeletal metastases in breast cancer patients. In addition, dosimetric analysis of 68Ga-NO2AP-BP was performed in a subset of patients.