Effects of N-methyl-D-aspartate receptor ligands on sensitivity to reinforcer magnitude and delayed reinforcement in a delay-discounting procedure

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• 作者：Justin R Yates ; Benjamin T Gunkel ; Katherine K Rogers…
• 关键词：Impulsive choice ; Delay discounting ; NMDA receptor ; Sensitivity to reinforcer magnitude ; Sensitivity to delayed reinforcement ; Rat
• 刊名：Psychopharmacology
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：234
• 期：3
• 页码：461-473
• 全文大小：
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Neurosciences; Pharmacology/Toxicology; Psychiatry;
• 出版者：Springer Berlin Heidelberg
• ISSN：1432-2072
• 卷排序：234

文摘

RationaleThe N-methyl-D-aspartate (NMDA) receptor has been recently identified as an important mediator of impulsive choice, as assessed in delay discounting. Although discounting is independently influenced by sensitivity to reinforcer magnitude and delayed reinforcement, few studies have examined how NMDA receptor ligands differentially affect these parameters.