Telmisartan increases systemic exposure to rosuvastatin after single and multiple doses, and in vitro studies show telmisartan inhibits ABCG2-mediated transport of rosuvastatin

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• 作者：Miao Hu ; Hon-Kit Lee ; Kenneth K. W. To…
• 关键词：ABCG2 ; Drug interaction ; Rosuvastatin ; Telmisartan
• 刊名：European Journal of Clinical Pharmacology
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：72
• 期：12
• 页码：1471-1478
• 全文大小：495 KB
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Biomedicine
  Pharmacology and Toxicology
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1432-1041
• 卷排序：72

文摘

PurposeThe ATP-binding cassette transporter G2 (ABCG2) plays an important role in the disposition of rosuvastatin. Telmisartan, a selective angiotension-II type 1 (AT1) receptor blocker, inhibits the transport capacity of ABCG2, which may result in drug interactions. This study investigated the pharmacokinetic interaction between rosuvastatin and telmisartan and the potential mechanism.